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SUMO-1 human
| 产品编号： | 4096453 |
| 规格： | ≥95% (SDS-PAGE), recombinant, expressed in E. coli (GST-tagged) |
| 包装规格： | 500 μG，1 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
SUMO-1 human
Sentrin-1
基本信息
| MDL number | MFCD03458656 |
| NACRES | NA.32 |
| General description【一般描述】 | Small ubiquitin-like modifier 1 (SUMO-1), a protein, is one of the 5 SUMO paralogs expressed in mammalian cells with a low but significant homology with ubiquitin. This SUMO-1-GST fusion protein is produced from a DNA sequence corresponding to human SUMO-1 fused to a glutathione S-transferase (GST)-tag and is expressed in E. coli cells. |
| Application【应用】 | SUMO-1 human has been used in pre-absorption for negative immunostaining to confirm the specificity of the small ubiquitin like modifier 1 (SUMO-1) antibody. |
| Biochem/physiol Actions【生化/生理作用】 | Small ubiquitin-like modifier 1 (SUMO-1) plays a key role in modulating survival, migration, and signal transduction in some cell lines. It can prevent in vitro migration and invasion of RA fibroblast-like synoviocytes (FLSs). Higher expression of SUMO-1 may result in joint destruction in rheumatoid arthritis (RA). Conjugated to a variety of proteins by UbcH9, including RanGAP1, IκBα, and PML without the requirement of an equivalent E3 ubiquitin ligase. |
| Physical form【外形】 | Solution in 50 mM HEPES, pH 8.0, 150 mM NaCl and 1 mM DTT. |
产品性质
| recombinant【重组】 | expressed in E. coli (GST-tagged) |
| Quality Level【质量水平】 | 200 |
| Assay【测定】 | ≥95% (SDS-PAGE) |
| mol wt【分子量】 | 38.5 kDa |
| UniProt accession no.【UniProt登记号】 | P63165 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −70℃ |
| Gene Information | human ... SUMO1(7341) |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |
