PP242 hydrate

C₁₆H₁₆N₆O · xH₂O

308.34 (anhydrous basis)

MFCD12828866

329819988

NA.77

PP242 hydrate has been used:

• as a mammalian target of rapamycin (mTOR) inhibitor to study its effects on rat fibroblast mTOR complex 1 and 2 (mTORC1 & 2) signaling
• as an mTOR inhibitor to treat mouse embryonic fibroblasts (MEF) and cumulus cells (CCs) to study its effects on reactivation of embryonic nucleoli and ribosome biogenesis
• as a target of rapamycin (TOR) kinase inhibitor for the treatment of Arabidopsis to study its effects against Fusarium graminearum infection

PP242 is a potent and selective mTOR inhibitor. PP242 is a first selective inhibitor that targets ATP domain of mTOR.

This compound is featured on the PKB/Akt page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

100

≥98% (HPLC)

powder

off-white

DMSO: >10 mg/mL

2-8℃

O.CC(C)n1nc(-c2cc3cc(O)ccc3[nH]2)c4c(N)ncnc14

1S/C16H16N6O.H2O/c1-8(2)22-16-13(15(17)18-7-19-16)14(21-22)12-6-9-5-10(23)3-4-11(9)20-12;/h3-8,20,23H,1-2H3,(H2,17,18,19);1H2

FMDOLJSFPXFBIL-UHFFFAOYSA-N

5, 25 mg in glass bottle

13 - Non Combustible Solids

WGK 2