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Pimelic Diphenylamide 106
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 3182173 | 5 MG | 1130 | |||
| 3182173 | 25 MG | 4160 |
产品别名
937039-45-7
Pimelic Diphenylamide 106
N1-(2-Aminophenyl)-N7-(4-methylphenyl)-heptanediamide
Compound 106
RGFA 8
TC-H 106
Inhibitor 106
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C20H25N3O2 |
| Molecular weight | 339.43 |
| MDL number | MFCD17010287 |
| PubChem Substance ID【PubChem化学物质编号】 | 329825318 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | Pimelic diphenylamides has the ability to enhance the expression of the frataxin gene in lymphocytes from Friedreich ataxia patients. 106 is a Class I HDAC inhibitor, demonstrating no activity against class II HDACs. It is a slow, tight-binding inhibitor of HDACs 1, 2, and 3, with a preference toward HDAC3 with Ki of 14 nM, 15 times lower than the Ki for HDAC1. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: ≥15 mg/mL |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | Cc1ccc(NC(=O)CCCCCC(=O)Nc2ccccc2N)cc1 |
| InChI | 1S/C20H25N3O2/c1-15-11-13-16(14-12-15)22-19(24)9-3-2-4-10-20(25)23-18-8-6-5-7-17(18)21/h5-8,11-14H,2-4,9-10,21H2,1H3,(H,22,24)(H,23,25) |
| InChI key | WTKBRPXPNAKVEQ-UHFFFAOYSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
