Cromakalim

C₁₆H₁₈N₂O₃

286.33

MFCD00133201

24891962

NA.77

Cromakalim has been used:

• as a potassium channel agonist to study its response to an acute increase in downstream pressure in rat lymphatic vessels.
• as a potassium channel opener to study its effects on the release of transmitters from adrenergic nerves in rat vas deferens.
• as a potassium channel activator to study its effects on the release of transmitters from purinergic and cholinergic nerves in the rat detrusor muscle.

Cromakalim is an activator of the potassium channel. It is involved in the relaxation of the vascular smooth muscles. Cromakalim exhibits anti-hypertensive activity.

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

200

2-8℃

CC1(C)Oc2ccc(cc2[C@H]([C@@H]1O)N3CCCC3=O)C#N

1S/C16H18N2O3/c1-16(2)15(20)14(18-7-3-4-13(18)19)11-8-10(9-17)5-6-12(11)21-16/h5-6,8,14-15,20H,3-4,7H2,1-2H3/t14-,15+/m1/s1

TVZCRIROJQEVOT-CABCVRRESA-N

rat ... Kcna1(24520), Kcnj1(24521), Kcnj5(29713), Kcnj8(25472)

10, 50 mg in glass bottle

13 - Non Combustible Solids

WGK 3

Eyeshields, Gloves, type N95 (US)